A Direct Synthesis of Vinylic Phosphonates from Vinylic Halides

Abstract

Approaches to the formation of vinylic phosphonates through direct replacement of a vinylic halide by phosphorus have received considerable attention. With the exception of α,β-unsaturated systems^1,2 attempts involving simple Michaelis-Arbuzov reaction conditions (heating, trivalent phosphorus ester) have failed.^3–5 Other efforts involving transition metal salts as catalysts have found greater, but still quite limited success.^6–8