Total Synthesis of (±)-Juneol and (±)-Acolamone

Abstract

Juneol¹ 1 and Acolamone² 2 are the two interesting eudesmane type sesquiterpenes whose synthetical investigations have recently received attention of organic chemists. Schwartz and associates realized a biogenetic-type synthesis³ of (±)-Juneol. The chemical transformation of the of the acetoxy ketone 3, obtained from α-santonine, to (+)-Juneol and (+)-Acolamone has been achieved.⁴ We wish to report an alternative approach for the synthesis of (±)-Juneol and (±)-Acolamone.⁵