Synthesis of 2-Hydroxy-4, 6-Dimethoxycrotonophenone A New Class of Natural Products from Dysophylla Stellata Benth

Abstract

2-Hydroxy-4, 6-dimethoxycrotonophenone (1), isolated from the plant Dysophylla stellata Benth. by Joshi and Ravindranath,¹ is the only example of an open chain form of chromanones. The co-occurrence of the crotonophenone (1) with chromone and butyrophenone¹ suggests that these are biogenetically related in the same way as chalcones are to flavonoids.² It is likely that more crotono-phenones and 2-methylchromanones will be discovered in nature.