A Convenient Synthesis of ω-Acetylenic Acids

Abstract

ω-Acetylenic acids are valuable intermediates in the synthesis of long-chain acids. Their dimagnesium salts may be alkylated with 1-bromo-2-alkynes or 2-alkenes to synthesize many important naturally occurring fatty acids^1–3. Also, internally-monounsaturated acids are prepared by alkylation of ω-acetylenic acid dilithium salts^4,5 or the sodium salts of their N,N-dimethylamides⁶.