α-Cyanation of Tertiary Amines

W. C. Groutas Department of Medicinal Chemistry, College of Pharmacy University of Minnesota, Minneapolis, MN, 55455

M. Essawi Department of Medicinal Chemistry, College of Pharmacy University of Minnesota, Minneapolis, MN, 55455

P. S. Portoghese Department of Medicinal Chemistry, College of Pharmacy University of Minnesota, Minneapolis, MN, 55455

Abstract

The α-cyanation of tertiary amines is customarily accomplished by mercuric acetate oxidation of the amine to form the enamine, which on treatment with base yields the corresponding Schiff's base. Subsequent treatment with aqueous potassium cyanide yields the desired product². Alternatively, and less commonly, the α-cyanation of tertiary amines can be carried out electrolytically^3,4

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α-Cyanation of Tertiary Amines

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α-Cyanation of Tertiary Amines

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