Abstract
7-endo-t-Butyldimethylsilyloxybicyclo[3.3.0]oct-8-en-2-one (7) is an important key intermediate for the synthesis of pharmacologically interesting prostacyclin analogs, 9(0)-methanoprostacyclin2 and 9(0)-methano-Δ6-PGI1.3 In addition it seems to be a valuable synthetic intermediate for the total synthesis of antitumor sesquiterpenoid coriolin family.4