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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 10, 1980 - Issue 1
116
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Original Articles

The Synthesis of Some 2-Substituted Morpholines

Pages 59-73 | Received 07 Aug 1979, Published online: 03 Jan 2007
 

Abstract

In connection with the synthesis of a number of compounds which were active as antidepressants, such as 2-(o-ethoxyphen-oxymethyl) morpholine (‘Vivalan’)1a and 2-styrylmorpholine,2 studies were directed towards the synthesis of suitable morpholine intermediates functionalised in the 2-position which could be readily made, preferably on a large scale.

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