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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 11, 1981 - Issue 10
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Original Articles

Phase Transfer Catalysis Preparation of Acyl Isothiocyanates

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Pages 781-785 | Published online: 05 Dec 2006
 

Abstract

The use of phase transfer catalysis, PTC, for nucleophillic substitution reactions is well documented.1,2 Included among these reactions is the preparation of both alkyl3 and aryl4 thiocyanates. However, PTC reactions at an acyl carbon are much less common. Brándstróm5 has reported the preparation of acyl azides and Weber6 has used PTC to prepare benzoyl cyanide. Recently Illi7 has used PTC to acylate sterically crowded phenols.

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