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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 12, 1982 - Issue 9
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Original Articles

A Convenient Synthesis of Azacycloheptanes

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Pages 733-737 | Published online: 05 Dec 2006
 

Abstract

Sucessful preparation of azacycloheptanes (and larger azacycloalkanes) via cyclization normally requires very high dilution conditions1,2. We wish to report a good yield synthesis of azacycloheptanes based on the ring closure of aminoalcohols with Raney nickel. This reagent has only been used to obtain piperazines and piperidines from 1,2-3 and 1,5-aminoalcohols4 respectively.

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