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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 12, 1982 - Issue 6
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Original Articles

Acetone Cyanohydrin, a Convenient Formylation Reagent for Arenes

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Pages 485-487 | Published online: 05 Dec 2006
 

Abstract

Numerous methods have been proposed for the formylation of aromatic derivatives1, including the Gatterman reaction which involves the use of hydrogen cyanide2. We report here the use of acetone cyanohydrin as an easy-to-handle formylation reagent for aromatic compounds:

Some results are summarized in the table.

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