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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 12, 1982 - Issue 6
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Original Articles

A Short and Economical Synthesis of 2,2,7,7-Tetramethyl-4-Octene -3,6-dione from 2-Furoic Acid and t-Butyl Chloride

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Pages 489-494 | Published online: 05 Dec 2006
 

Abstract

2,2,7,7-Tetramethyl-4-octene-3,6-dione (5), a useful synthetic intermediate, 1was required in kilogram quantities for further structural elaboration. Previous synthesis of (5) have given low yields 2 or have required unstable, 3 lachrymatory 4 or prohibitively expensive 5 intermediates. (5) has now been prepared in 43% overall yield by a route well suited to large scale operation (scheme)

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