Ketene-S, N-Acetals As Synthetic Intermediates of Heterocycles. New Synthesis of Uracil and Barbituric Acid Derivatives

Abstract

The importance of enamines for organic synthesis is well documented.¹ Ketene-S,N-acetals2 derived from tertiary thioamides are α-alkylthiosubstituted enamines and expected to work as the synthetic equivalent of an enolate anion³. We have been interested in exploring their synthetic utility as the intermediates of heterocycles.⁴