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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 14, 1984 - Issue 9
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Original Articles

Chlorosulfates as Reagents in the Synthesis of Carboxylic Acid Esters Under Phase-Transfer Conditions

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Pages 857-864 | Published online: 19 Dec 2006
 

Abstract

During a search for a satisfactory synthesis of chloromethyl esters 1 of certain β-lactam antibiotics, e.g. penicillanic acid sulfone, we discovered that chloromethyl chlorosulfate1 (4) is an excellent reagent for this purpose. We also found that other alkyl chlorosulfates are useful reagents for the synthesis of the corresponding alkyl carboxylates.

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