Solid-Liquid Phase Transfer Catalysis Without Solvent: A Mild and Efficient Preparation of Mono and Di-Ethers Derived from 8-Hydroxyquinoline

Abstract

The title compounds are easily prepared by reaction of 8-hydro-xyquinoline with either 1 eq. C_nH_2n+1Br (2≤n≤l6) or 0.5 eq. Br(CH₂)_nBr (3≤n≤6) in the presence of 1 eq. finely ground KOH and 2 % Aliquat 336. Reactions are performed in the absence of any organic solvent. Yields and experimental conditions compare very favourably to those obtained previously by classical methods.