2,4-Dichloro-5-Nitropyrimidine as a New Dehydrating or Desulfhydrating Reagent

Abstract

It has been reported that cyanuric chloride can be used as both dehydrating and desulfhydrating reagents for the synthesis of carbodiimides¹), lactones²), isonitriles³), acid halides^4,5) and alkyl phosphates⁶). In connection with a series of our comprehensive studies on nucleic acid analogs, we found similarly that some chloropyrimidines such as 2,4-dichloro- and 2,4,6-trichloropyrimidine can be used effectively for a variety of dehydration and desulfhydration reactions⁷⁾. These reactions were characterized by the process via lactimlactam transformation of the pyrimidine ring.