Reduction of Phenyl-Substituted Pyridinium Methoiodides with Sodium Borohydride. Formation of Amine-Borane Complexes in Water

Wieslaw Gessner Section on Medicinal Chemistry, Laboratory of Chemistry, NIADDK National Institutes of Health, Bethesda, Maryland, 20205

Arnold Brossi Section on Medicinal Chemistry, Laboratory of Chemistry, NIADDK National Institutes of Health, Bethesda, Maryland, 20205

Abstract

Reduction of phenyl-substituted pyridinium methoiodides with sodium borohydride in water afforded besides the desired tetrahydropyridines substantial amounts of amine-borane complexes. Reduction in methanol afforded tetrahydropyridines in high yield, with almost no amine-boranes formed.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Reduction of Phenyl-Substituted Pyridinium Methoiodides with Sodium Borohydride. Formation of Amine-Borane Complexes in Water

Information for

Open access

Opportunities

Help and information

Reduction of Phenyl-Substituted Pyridinium Methoiodides with Sodium Borohydride. Formation of Amine-Borane Complexes in Water

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature