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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 16, 1986 - Issue 7
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Original Articles

A Convenient Synthesis of Aminomethylphosphonic Acid

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Pages 733-739 | Published online: 06 Dec 2006
 

Abstract

A novel procedure for the preparation of aminometnylphosphonic acid (AMPA) is described. This compound. which has been shown to have some biological activity, is synthesized by treating N-hydroxymethylbenzamide with a mixture of phosphorous trichloride and trimethyl phosphite, followed by hydrolysis of the ester intermediate.

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