An Expeditious Synthesis of 4(5) [3-Aminopropyl] Imidazole

Abstract

Inpmmidine 1is a highly potent and selective agonist for histamine receptors.¹ The synthesis of inpmnidine and structure activity considerations have recently been described. Inpmmidine also has potential valus for the tEatrnent of catecholamine-insensitive congestive heart failure.³ It has been noted,³ however, that the synthesis of inpromidine is too canplicated and very expensive. One reason for this is the difficulty associated with the synthesis of the crucial inter mxiiate 4(5) [3-aminopmpyl] imidazole 2hereafter referred to as imi damlylpmpylamine.