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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 17, 1987 - Issue 16
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Original Articles

Synthesis of Deoxytabtoxinine-β-Lactam

Barry B. Snider Department of Chemistry, Brandeis University, Waltham, MA, 02254
&
Madeline I. Johnston Department of Chemistry, Brandeis University, Waltham, MA, 02254
Pages 1877-1886 | Published online: 06 Dec 2006
 
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Abstract

Deoxytabtoxinine-β-lactam (12) was synthesized in 6 steps from 3. β-Lactam 12 does not inhibit glutamine synthetase indicating that the hydroxyl group of tabtoxinine-β-lactam (2) is necessary for inhibition of glutamine synthetase.

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