Publication Cover
Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 17, 1987 - Issue 4
48
Views
7
CrossRef citations to date
0
Altmetric
Original Articles

Syutheses of the Major Metabolites of (2E,4E,6E,8E)- and (22,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-Trimethyl-1-Cyclohexen-1-YL)-2,4,6,8-Nonatetraenoic Acids (Retinoic Acid and 13-cis-Retinoic Acid)

, , , , &
Pages 419-429 | Published online: 05 Dec 2006
 

Abstract

Wittig condensation of (2E,4E)-[5-(3-oxo-2,6,6-trimethyl-1-cyclohexen-1-yl)-3-methyl-2,4-pentadienyl]triphenylphosphonium bromide with ethyl formylcrotonate or 4-hydroxy-3-nethylbutenolide gives, respectively, the (all-E) and (22,4Z)-3,7-dimethyl-9-(2,6,6-trimethyl-3-oxo-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acids. These are converted to oxo and hydroxy metabolites of retinoic acid and 13-cis-retinoic acid.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.