A General Method for the Preparation of 2,2,4-Trimethyl and 2,2-Dimethyl-4-Isophopyl-6-Hydhoxy-7-Substituted Cheomans

Abstract

2,2,4-Trimethyl and 2,2-dimethyl-4-isopropyl-6-hydroxy-7-substituted chromans can be conveniently prepared by the reaction of 2-substituted hydroquinones with 2-methyl-2,4-pentanediol or 2,5-diraethyl-2,5-hexanediol, respectively, in the presence of macroreticular strongly acidic sulfonic acid cation exchange resin catalysts. The reaction is positionally selective and allows for simple workups and reasonable yields.