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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 17, 1987 - Issue 7
84
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Original Articles

Synthesis of N-Unsubstituted α-Alkylated Pyrrol-2-Acetonitriles

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Pages 863-875 | Published online: 05 Dec 2006
 

Abstract

Nucleophilic addition of alkyllithium compounds to in situ generated 6-dimethyl-amino-1-azafulvene produced the α-alkylated pyrrole Mannich bases (3). Reaction of the p-toluenesulfonic acid salt of such bases with excess sodium cyanide in wet acetonit-rile. at reflux temperature, provided the corresponding α-alkylpyrrol-2-acetonitriles (5) via the putative 6-alkyl-1-azafulvenes (4).

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