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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 17, 1987 - Issue 9
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Original Articles

An Efficient Synthesis of 3-Cyano-1(3H)-Isobehzofuranones

Kousuke Okazaki Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Sugitani 2630, Toyama, 930-1, Japan
,
Keiichi Nomura Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Sugitani 2630, Toyama, 930-1, Japan
&
Eiichi Yoshii Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Sugitani 2630, Toyama, 930-1, Japan
Pages 1021-1027 | Published online: 19 Dec 2006
 
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Abstract

Reaction of o-formyl-N, N-diethylbenzamides (5) with trimethylsilyl cyanide affords the corresponding (0-trimethylsi-lyl)cyanohydrins (6), which on treatment with acetic acid produce 3-cyanophthalides (7) in 80–90% isolated yields.

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