Publication Cover
Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 17, 1987 - Issue 9
67
Views
2
CrossRef citations to date
0
Altmetric
Original Articles

A Novel Approach to Synthesis of 1R-Cis-Caronaldehyde a key Intermediate for Photostable Pyrethroid Insecticides

, &
Pages 1089-1094 | Published online: 19 Dec 2006
 

Abstract

The bicyclic hydroxy γ-lactone, cis-(-)-4 α-hydroxy-6, 6-dimethyl-3-oxa-bicyclo (3, 1, 0)-hexan-2-one (1), commonly known a s 1R-cis-caronaldehyde, is an important intermediate for the highly potent pyrethroids Deltamethrin (2) and NRDC 182 (2). The latter is the biologically active isomer in commercial cypermethrin. In our laboratory we have obtained excellent yields of (1) by the reductive ozonolysis2 of the enol lactone 4 obtained by the cyclization of the keto acid (2) which in turn is derived from the abundantly available (+)-3-carene.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.