The Regioselectivity of Deprotonation of Unsymmetrical Ketones with Lithium Tert-Butyltrialkylsilyl Amides

J. Antonio Prieto Department of Chemistry, University of Puerto, Rico Rio Piedras, P.R., 00931; Petrarch Systems, Bartram Road, Bristol, PA, 19007

Juan Suarez Department of Chemistry, University of Puerto, Rico Rio Piedras, P.R., 00931; Petrarch Systems, Bartram Road, Bristol, PA, 19007

Gerald L. Larson Department of Chemistry, University of Puerto, Rico Rio Piedras, P.R., 00931; Petrarch Systems, Bartram Road, Bristol, PA, 19007

Abstract

The regioselectivity of deprotonation of 2-methylcyclohexanone, 2-heptanone, phenylacetone,4-methyl-2-pentanone, trimethylsilyl acetone and 3-methyl-2-pentanone with the lithium salt of the readily prepared ^tBuNHSiR₃ amines, where the silyl group is trimethyl, triethyl, tert-butyldimethyl and methyldiphenylsilyl was investigated.

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The Regioselectivity of Deprotonation of Unsymmetrical Ketones with Lithium Tert-Butyltrialkylsilyl Amides

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The Regioselectivity of Deprotonation of Unsymmetrical Ketones with Lithium Tert-Butyltrialkylsilyl Amides

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