A Convenient Preparation of (R)-7-(3-Benzothienylglycylamido)deacetoxycephalosopranic Acid

Douglas W. Balogh Eli Lilly and Company Lilly Corporate Center, Indianapolis, Indiana, 46285

Lawrence E. Patterson Eli Lilly and Company Lilly Corporate Center, Indianapolis, Indiana, 46285

William J. Wheeler Eli Lilly and Company Lilly Corporate Center, Indianapolis, Indiana, 46285

Abstract

An efficient synthesis of (R)-7-(3-benzothienylamido)deacetoxy-cephalosporanic acid (1) is described beginning from (R)-alpha-aminobenzo[b]thiophene-3- acetic acid (2) and 7-amino-3-methyl-3-cephem-4-carboxylic acid (7-ADCA). Good yields were obtained and the procedure is amenable to multikilogram preparations.

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A Convenient Preparation of (R)-7-(3-Benzothienylglycylamido)deacetoxycephalosopranic Acid

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A Convenient Preparation of (R)-7-(3-Benzothienylglycylamido)deacetoxycephalosopranic Acid

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