A Mild Single-Step Reduction of Oximes to Amines1 : Synthetic Communications: Vol 18, No 8

Synthetic Communications

An International Journal for Rapid Communication of Synthetic Organic Chemistry

Volume 18, 1988 - Issue 8

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Abstract

A mild and convenient procedure has been developed for the reduction of oximes to amines in a single step involving treatment of the oxime with TiCl₃ in the presence of NaBH₃ CN. This method is especially useful for those substrates in which the intermediate imine is readily hydrolyzed.

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A Mild Single-Step Reduction of Oximes to Amines¹

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A Mild Single-Step Reduction of Oximes to Amines¹