A Convenient Synthesis of N-Alkyl and N, N-Dialkyltrifluoroacetamides in a Solid-liquid Two-Phase System in the Presence of Phase-Transfer Catalysts

Abstract

Trifluoroacetamide is easily monoalkylated in a K₂ CO₃-organic solvent solid-liquid two-phase system affording in good to excellent yields N-alkyltrifluoroacetamides. Under the same conditions, the latter, in turn, react with alkylating agents giving N, N-dialkyltrifluoroacetamides in high yields.