A Two-Step Synthesis Of S-Methyl Dinucleoside Phosphorothioates

Pier Bartolomeo Caruso Dipartimento di Chimica, Universita' della Calabria, I-87030, ARACAVACATA DI RENDE (CS), Italy

Angelo Liguori Dipartimento di Chimica, Universita' della Calabria, I-87030, ARACAVACATA DI RENDE (CS), Italy

Giovanni Sindona Dipartimento di Chimica, Universita' della Calabria, I-87030, ARACAVACATA DI RENDE (CS), Italy

Nicola Uccella Dipartimento di Chimica, Universita' della Calabria, I-87030, ARACAVACATA DI RENDE (CS), Italy

Abstract

S-methyl dinucleoside phosphorothioates are prepared from 0-2,4-dichlorophenyl S-methyl nucleoside phosphorothioates by selective removal of the transient 0-2,4-dichlorophenyl protecting group followed by condensation with appropriate nucleosides in the presence of MSNT activating reagent.

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A Two-Step Synthesis Of S-Methyl Dinucleoside Phosphorothioates

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A Two-Step Synthesis Of S-Methyl Dinucleoside Phosphorothioates

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