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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 18, 1988 - Issue 8
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Original Articles

An Efficient Method for the Iodination of C5-Position of Dialkoxy Pyrimidines and Uracil Bases1,2

Biswajit Das Department of Organic Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Calcutta, 700032, INDIA
&
Nitya G. Kundu Department of Organic Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Calcutta, 700032, INDIA
Pages 855-867 | Published online: 05 Dec 2006
 
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Abstract

N-Iodosuccinimide in trifluoroacetic acid and trifluoroacetic anhydride was found to be an excellent reagent for the conversion of 2,4-dialkoxy pyrimidines to 2,4-dialkoxy-5-iodopyrimidines. Iodination at C5-position of uracil and its derivatives was also accomplished with the above reagent.

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