Synthesis of (+)-l-[(lα,2α,3β,4α)-2,3-Dihydroxy-4-Hydroxymethyl] -5-Methyl-2,4-(1H, 3H) Pyrimidinedione, the Carbocyclic Analogue of Ara-T

Abstract

Abstract-Compound 1, the carbocyclic analogue of Ara-T, was synthesized by a four-step synthesis from (+)-(lα,2α,3β,5β)-3-amino-5-(hydroxymethyl)-l,2,-cyclopemane-diol (2), which was prepared from cyclopentadiene via a eight-step route as a potential antiviral agent.