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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 18, 1988 - Issue 9
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Original Articles

Convenient Synthesis of the Food Mutagen 2-Amino-3-Methylimidazo[4,5-f]Quinoline (IQ), and IQ-D3

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Pages 973-980 | Published online: 05 Dec 2006
 

Abstract

The title compounds (5 and 10) were each prepared in four steps from commercially available 5-amino-6-nitroquinoline (1) in 41% overall yield. The key step was the displacement of the methylsulfonyl group of 4 by sodamide.

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