Asymmetric Syntheses Vi: Asymmetric Aldol Reaction of D-Camphor Imine Derived From Benzylamine

Abstract

Addition of the D-camphor imine of benzylamine to a variety of aldehydes or ketones gives diastereose-lectivities ranging from 16–70%. The d.e. value is attributed by the difference of the orientation of C-11 groups. The rotation of (5e) indicates that addition reaction occurs from the pro-R face of lithium derivative (2).