(S)-(−)-2-Methyl-2-Phenylsuccinic Anhydride, a Novel Resolving Reagent and its Application to Resolution of CIS-5-Amino-4-Phenyl-1,3-DIOXANE

Abstract

A new resolving reagent, (S)-(−)-2-methyl-2-phenylsuccinic anhydride (5) for the resolution of amines via covalent bond formation and its application to the resolution of aminodioxane (±)-(1) is described. The d.e. of the amides (7) and (8) has been determined by studying ¹H-NMR spectra.