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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 18, 1988 - Issue 16-17
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Original Articles

A Convenient Method for the Large Scale Preparation of (E)-4-Oxo-2-Butenoic Acid Ethyl Ester

Robert G. Franz Department of Medicinal Chemistry, Research & Development Smith Kline & French Laboratories, 709 Swedeland Road, Swedeland, PA, 19479
&
Joseph Weinstock Department of Medicinal Chemistry, Research & Development Smith Kline & French Laboratories, 709 Swedeland Road, Swedeland, PA, 19479
Pages 1913-1917 | Published online: 05 Dec 2006
 
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Abstract

A one step synthesis of (E)-4-oxo-2-butenoic acid ethyl ester via the reaction of ethyl 2-ethoxy-2-hydroxyacetate and (formylmethylene)triphenylphosphorane is described. The method proceeds in good yield on a molar scale.

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