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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 18, 1988 - Issue 16-17
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Original Articles

Novel Synthesis of 3-Fluoro-1-Aminoadamantane and Some of its Derivatives

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Pages 1967-1974 | Published online: 05 Dec 2006
 

Abstract

The title compound, 3-fluoro-1-aminoadamantane, isolated as the hydrochloride, has been synthesized in a three-step reaction sequence which is both convenient and rapid. Three derivatives of the amine, 3-fluoro-1-(N-adamantyl)-p-toluenesulfonamide, 3-fluoro-1-(N-adamantyl) benzamide, and 3-fluoro-1-methyl-(N-adamantyl) carbamate, have also been prepared. All compounds were characterized by the usual methods.

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