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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 18, 1988 - Issue 7
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Original Articles

Conjugate Addition of Grignard Compounds to 2-Benzyl-6-Oxo-Octahydroisoquinoline in the Presence of Copper-Thiophenolate

W. Bartmann HOECHST Aktiengesellschaft, Pharma Synthese Postfach 80 03 20, D-6230, Frankfurt 80, FRG
,
E. Guntrum HOECHST Aktiengesellschaft, Pharma Synthese Postfach 80 03 20, D-6230, Frankfurt 80, FRG
,
H. Urbach HOECHST Aktiengesellschaft, Pharma Synthese Postfach 80 03 20, D-6230, Frankfurt 80, FRG
&
J. Wunner HOECHST Aktiengesellschaft, Pharma Synthese Postfach 80 03 20, D-6230, Frankfurt 80, FRG
Pages 711-715 | Published online: 19 Dec 2006
 
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Abstract

In the presence of copper-thiophenolate, the conjugate addition of various Grignard compounds to an α, β-unsaturated octahydroisoquinolinone is improved.

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