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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 18, 1988 - Issue 14
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Original Articles

A Mild and Facile Route to ω-Amino Esters

Royce Menezes Department of Chemistry, University of Connecticut, Storrs, U-60, Rm. 151, 215 Glenbrook Rd, Connecticut, 06268, U.S.A.
&
Michael B. Smith Department of Chemistry, University of Connecticut, Storrs, U-60, Rm. 151, 215 Glenbrook Rd, Connecticut, 06268, U.S.A.
Pages 1625-1636 | Published online: 03 Jan 2007
 
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Abstract

Lactim ethers are conveniently prepared from the corresponding lactam. The salt prepared by protonation with HC1 or HBF4sb> is hydrclyzed in neutral water at ambient temperatures to give good yields of the ω-amino ester.

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