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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 18, 1988 - Issue 14
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Original Articles

Vanillin (1) As Starting Material for the Synthesis of Isomeric Phthalides

Paulo R. R. Costa Núcleo de Pesquisas de Produtos Naturais, Univcrsidade Federal do Rio de Janeiro, Centro de Ciěncias da Saúde, Bloco H, 21941, Rio de Ja neiro, RJ, Brazil
,
ClÁUdio C. Lopes Departamento de Química Analítica, Instituto de Química, UFRJ
,
Ros[acaron]ngela S. C. Lopes Departamento de Tecnologia Farmacěutica, Facuj. dade de Farmácia, UFRJ
,
Maria F. G. Marinho Núcleo de Pesquisas de Produtos Naturais, Univcrsidade Federal do Rio de Janeiro, Centro de Ciěncias da Saúde, Bloco H, 21941, Rio de Ja neiro, RJ, Brazil
&
Rosane N. Castro Núcleo de Pesquisas de Produtos Naturais, Univcrsidade Federal do Rio de Janeiro, Centro de Ciěncias da Saúde, Bloco H, 21941, Rio de Ja neiro, RJ, Brazil
Pages 1723-1730 | Published online: 03 Jan 2007
 
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Abstract

Phthalides have bcen employed as useful intcriucdiates in tic sqrnthcsis of my condcnscld aromatic carbocyclic and heterocyclic compounds, including several natural products In this paper we report two alternative synthetic pathways for the preparation of phthalides as shown for the synthesis of the isomeric pairs of compounds 5a-d and 7a-d.

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