Carboxyethyl Homologation of Lactols: Synthons For Dinorprostanoids

Chandra Prakash Department of Pharmacology, Vanderbilt University, Nashville, Tennessee, 37232, USA

Samir Saleh Department of Pharmacology, Vanderbilt University, Nashville, Tennessee, 37232, USA

Ian A. Blair Department of Pharmacology, Vanderbilt University, Nashville, Tennessee, 37232, USA

Abstract

Synthons derived by three carbon homologation of suitably functionalized lactols are key intermediates in the preparation of dinor prostaglandin metabolites. An efficient method for the synthesis of dinor prostaglandin synthons with the desired Z-5, 6 double bond geometry is described.

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Carboxyethyl Homologation of Lactols: Synthons For Dinorprostanoids

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Carboxyethyl Homologation of Lactols: Synthons For Dinorprostanoids

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