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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 18, 1988 - Issue 18
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Original Articles

A Novel Synthesis of Ketoprofen, Important Non-Steroidal Antiinflammatory Agent

R. B. Mitra National Chemical Laboratory, Pune, 411 008, India
&
Vijaya S. Joshi National Chemical Laboratory, Pune, 411 008, India
Pages 2259-2265 | Published online: 03 Jan 2007
 
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Abstract

The α-propionic acid moiety in. ketoprofen is attached through Wittig Homer reaction of ethyl-phosphono propionate on 3-benzyl cyclohexanone, prepared by G. reaction of benzylmagnesium chloride with 2-cyclohexenone (in presence of cuprous chloride)

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