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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 19, 1989 - Issue 13-14
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Original Articles

A Short and Convenient Synthesis of 5-Alkyl Substituted 8-Hydroxyquinolines

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Pages 2273-2282 | Received 03 Apr 1989, Published online: 24 Oct 2006
 

Abstract

5-Chloro-8-methoxyquinoline undergoes rapid and reversible lithium-halogen exchange reaction with alkyllithiums to yield 5-alkyl substituted derivatives indirectly, whereas the reaction with phenyllithium is slower and 5-alkyl substituted compounds are formed by the direct addition of alkyl halides.

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