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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 19, 1989 - Issue 13-14
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Original Articles

Diisobutylaluminum Hydride Reduction of Unsaturated Sylylcyanohydrins: A New Entry to Confertifolin

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Pages 2467-2480 | Received 30 Mar 1989, Published online: 24 Oct 2006
 

Abstract

A new entry to the drimane-related sesquiterpene Confertifolin is reported. The key step involves the conversion of a β-phenylthio-α, β-unsaturated ketone into the corresponding silylcyanohydrin followed by diisobutylaluminum hydride reduction to the homologous α,β-unsaturated aldehyde.

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