Synthesis of Dothiepin and Doxepin by Grignard Reactions in Toluene

Lars Jalander Department of Organic Chemistry, Åbo Akademi, SF-20500, ÅRbo, Finland

Lasse Oksanen Department of Organic Chemistry, Åbo Akademi, SF-20500, ÅRbo, Finland

Johanna ähtinen Department of Organic Chemistry, Åbo Akademi, SF-20500, ÅRbo, Finland

Abstract

The tricyclic antidepressant agents 11-(3-N,N-dimethyIammopropylidene)-6H, 11H-dibenzo-[p,e]-thiepin hydrochloride (Dothiepin) and 11-(3-N,N-dimethylamino-propylidene)-6H,11H-dibenzo-[b,e]oxepin hydrochloride (Doxepin) have been prepared in good yield by Grignard reactions in toluene.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Synthesis of Dothiepin and Doxepin by Grignard Reactions in Toluene

Information for

Open access

Opportunities

Help and information

Synthesis of Dothiepin and Doxepin by Grignard Reactions in Toluene

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature