Regio- and Chemoselective N-C Bond Formation Via Carbon Dioxide: A New Source of the Methyl Group. Applications to N-Methylated Secondary and Tertiary Amines

Abstract

Reductive carboxylation of a variety of secondary and primary amines to the corresponding N-methylated amines in the presence of various functional groups such as chlorosubstituents, carbon-carbon double bonds and phenolic hydroxyls is described.