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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 19, 1989 - Issue 20
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Original Articles

A New Synthesis of O-Benzyl-L-Threonine

Shui-Tein Chen Institute of Biological Chemistry, Academia Sinica and Institute of Biochemical Sciences, National Taiwan University, P. O. Box 23 -106, Taipei, 10098, Taiwan ROC
,
Shih-Hsiung Wu Institute of Biological Chemistry, Academia Sinica and Institute of Biochemical Sciences, National Taiwan University, P. O. Box 23 -106, Taipei, 10098, Taiwan ROC
&
Kung-Tsung Wang Institute of Biological Chemistry, Academia Sinica and Institute of Biochemical Sciences, National Taiwan University, P. O. Box 23 -106, Taipei, 10098, Taiwan ROC
Pages 3589-3593 | Received 21 Jul 1989, Published online: 24 Oct 2006
 
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Abstract

O-Benzyl-L-threonine can be prepared in a one-pot synthesis in 80% yield by using ethyl acetoacetate to protect the α-amino group, followed by treatment with benzyl bromide and removal of the N-protecting group under acidic conditions.

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