Asymmetric Syntheses V: Asymmetric Alkylation of D-Camphor Imine of 1-Aminomethyl Naphthalene

Abstract

Alkylation of the D-camphor imine of 1-amino-methyl naphthalene with a variety of alkylating agents gave diastereoselectivities ranging from 20–64%. The de ratio in the alkylation could be determined by the chemical shift difference of ¹H-NMR signals of the C-8 methyl groups or by ¹³C-NMR signals in the C-7 of compound (6).