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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 20, 1990 - Issue 18
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Original Articles

A New Synthesis of 3-Alkyl Isoxazoles

L. Dasaradhi Indian Institute of Chemical Technology, Hyderabad, 500 007, India
,
S. Jagadishwar Rao Indian Institute of Chemical Technology, Hyderabad, 500 007, India
&
U. T. Bhalerao Indian Institute of Chemical Technology, Hyderabad, 500 007, India
Pages 2799-2804 | Received 05 Jul 1990, Published online: 24 Oct 2006
 
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Abstract

A two step facile synthesis of isoxazoles is described. The synthesis involves copper catalysed bromoform addition to an alkene (1) to afford tribromo derivative (2) which on treatment with sodiumnitrite in DMF gives the corresponding isoxazole (3).

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