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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 20, 1990 - Issue 7
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Original Articles

A Convenient Large-Scale Synthesis of Cyclobutyl Halides

Andrea C. Dupont Nova Pharmaceutical Corporation, 6200 Freeport Centre, Baltimore, Maryland, 21224
,
Vicki H. Audia Nova Pharmaceutical Corporation, 6200 Freeport Centre, Baltimore, Maryland, 21224
,
Philip P. Waid Nova Pharmaceutical Corporation, 6200 Freeport Centre, Baltimore, Maryland, 21224
&
J. Paul Carter Nova Pharmaceutical Corporation, 6200 Freeport Centre, Baltimore, Maryland, 21224
Pages 1011-1021 | Received 04 Jan 1990, Published online: 24 Oct 2006
 
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Abstract

An improved method for the preparation of multigram quantities of cyclobutyl halides is described. The Grignard reactivity of these halides with aldehydes is also discussed.

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