One-Pot Synthesis of Thiazolidino [3,2-a] Pyrimidine Derivatives

Edwige Jeanneau-Nicolle Groupe de Pharmacochimie Moléculaire, Laboratoire de Chimie Organique, UFR de Pharmacie - Université Joseph Fourier, (Grenoble I), BP 138, 38240, Meylan-Cedex, France

Martine Benoit-Guyod Groupe de Pharmacochimie Moléculaire, Laboratoire de Chimie Organique, UFR de Pharmacie - Université Joseph Fourier, (Grenoble I), BP 138, 38240, Meylan-Cedex, France

Gérard Leclerc Groupe de Pharmacochimie Moléculaire, Laboratoire de Chimie Organique, UFR de Pharmacie - Université Joseph Fourier, (Grenoble I), BP 138, 38240, Meylan-Cedex, France

Abstract

Reaction of 2-aminothiazoline with an aromatic aldehyde and an activated methylene group (malonitrile, diethylmalonate or ethylcyanoacetate) gave the title compounds. The structures are unambiguously assigned using spectroscopic data and chemical proofs.

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One-Pot Synthesis of Thiazolidino [3,2-a] Pyrimidine Derivatives

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One-Pot Synthesis of Thiazolidino [3,2-a] Pyrimidine Derivatives

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